Northwestern vs. No. 19 USC odds, line: 2025 college football picks for Week 11 predictions from proven model

The 19th-ranked USC Trojans will look to stay in the Big Ten title chase when they battle the Northwestern Wildcats on Friday night. USC is coming off a 21-17 win at Nebraska this past week, while Northwestern dropped a 28-21 decision at Nebraska on Oct. 25. The Wildcats (5-3, 3-2 Big Ten), who are tied for eighth in the conference, are 1-2 on the road this season. The Trojans (6-2, 4-1 Big Ten), who are tied for fourth, are 4-0 on their home field in 2025. USC running back Waymond Jordan (ankle) is doubtful.

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Kickoff from the Los Angeles Memorial Coliseum is at 9 p.m. ET. USC leads the all-time series 5-0. The teams last met in the 1996 Rose Bowl, which the Trojans won 41-32. The Trojans are 13.5-point favorites in the latest Northwestern vs. USC odds, while the over/under for total points scored is 50.5 via SportsLine consensus.  

Before making any Northwestern vs. USC picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks. Anyone following could have seen impressive returns.

The model has simulated Northwestern vs. USC 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in well over 50% of simulations.

So who wins Northwestern vs. USC, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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