The Northwestern Wildcats will take on the Duke Blue Devils at noon ET on Saturday at Ryan Field. The Wildcats opened the year with a 31-28 win over Nebraska, while Duke blew out Temple in a 30-0 final. The Wildcats are favored by 9.5 points in the latest Northwestern vs. Duke odds from Caesars Sportsbook, and the over/under is set at 54. 

Before you make any Duke vs. Northwestern picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It enters Week 2 of the 2022 college football season on a 48-37 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, it has simulated Northwestern vs. Duke 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Northwestern vs. Duke? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!