Northern Illinois vs. Vanderbilt odds, line, spread: Proven model reveals college football picks, predictions for Week 3, 2022

The Northern Illinois Huskies will take on the Vanderbilt Commodores at 3:30 p.m. ET on Saturday at Brigham Field at Huskie Stadium on CBS Sports Network. Vanderbilt's 2-0 start to the season was upended by No. 23 Wake Forest in a 45-25 blowout last week, while Northern Illinois is coming off a 38-35 loss to Tulsa. The Huskies are favored by 2.5 points in the latest Northern Illinois vs. Vanderbilt odds from Caesars Sportsbook, and the over/under is set at 59.5. 

Before you make any Vanderbilt vs. Northern Illinois picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It enters Week 3 of the 2022 college football season on a 50-41 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, it has simulated Northern Illinois vs. Vanderbilt 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Northern Illinois vs. Vanderbilt? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.