Northern Illinois vs. UMass odds, line: 2025 college football picks for Week 12 predictions from proven model

Teams at the bottom of the MAC standings will collide on Wednesday as the UMass Minutemen host the Northern Illinois Huskies. Massachusetts (0-9, 0-5 MAC) is the lone winless team in all of FBS and is coming off a 44-10 defeat to Akron last Tuesday. NIU (2-7, 1-4 MAC) was throttled by Toledo, 42-3, in its last contest on November 5.

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Kickoff is at 7 p.m. ET from Warren McGuirk Alumni Stadium in Amherst, Mass. The Huskies are 10.5-point favorites in the latest Northern Illinois vs. UMass odds, while the over/under for total points scored is 43.5 via SportsLine consensus. 

Before making any UMass vs. Northern Illinois picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks. Anyone following could have seen impressive returns.

The model has simulated Northern Illinois vs. UMass 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits nearly 60% of the time!

So who wins UMass vs. Northern Illinois, and which side of the spread hits almost 60% of the time? Join SportsLine right now to see which side of the Northern Illinois vs. UMass spread you need to jump on, all from the computer model that has crushed its college football picks!

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