North Carolina vs. Ole Miss odds, prediction: 2025 NCAA Tournament picks from proven model

The No. 11 seed North Carolina Tar Heels and the No. 6 seed Ole Miss Rebels match up in the first round of the 2025 NCAA Tournament on Friday. The Tar Heels are fresh off a dominating 95-68 win over San Diego State in the First Four contest to lock down the No. 11 seed. In the meantime, the Rebels have lost two of their last three games and logged a 22-11 record in the regular season. 

Tipoff from the Fiserv Forum in Milwaukee, Wis., is set for 4:05 p.m. ET. North Carolina is a 1.5-point favorite in the latest North Carolina vs. Ole Miss odds from SportsLine consensus, while the over/under for total points scored is 155.5.

Before making any North Carolina vs. Ole Miss picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters the 2025 NCAA Tournament on a 228-166 roll (+2025) on all top-rated college basketball picks dating back to 2023. This model has also produced brackets that have beaten over 91% of CBS Sports entries in four of the last six tournaments and nailed 24 first-round upsets by double-digit seeds! Anyone following could have seen HUGE returns!

The model has simulated North Carolina vs. Ole Miss 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread cashes in nearly 60% of simulations!

So who wins North Carolina vs. Ole Miss, and which side of the spread cashes in nearly 60% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is 228-166 (+2025) on top-rated college basketball pick and has nailed 24 double-digit upsets!