North Carolina vs. Notre Dame odds, prediction: 2026 college basketball picks for Jan. 21 from proven model

The 22nd-ranked North Carolina Tar Heels take on the Notre Dame Fighting Irish in ACC hoops action on Wednesday. UNC is 14-4 overall, but just 2-3 in the ACC. Notre Dame is 10-8 (1-4) ACC and has dropped four straight. 

Tipoff from the Dean E. Smith Center in Chapel Hill, N.C., is at 7 p.m. ET. The Tar Heels are 11.5-point favorites in the latest UNC vs. Notre Dame odds, while the over/under is 148.5. 

Before making any Notre Dame vs. UNC picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 12 on a sizzling 10-1 run on top-ranked over/under picks. Anyone following could have seen HUGE returns!

The model has simulated UNC vs. Notre Dame 10,000 times and the results are in. The model is leaning Under, and it also says one side of the spread hits in well over 50% of simulations!

So who wins Notre Dame vs. UNC, and which side hits in well over 50% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!