The second-ranked Duke Blue Devils will look to win their 15th game in a row when they battle their archrival North Carolina Tar Heels in a key Atlantic Coast Conference matchup on Saturday. North Carolina is coming off a 73-65 loss at Pittsburgh on Tuesday, while Duke defeated North Carolina State 74-64 on Monday. The Tar Heels (13-9, 6-4 ACC), who are seventh in the conference, are 3-4 on the road this season. The Blue Devils (18-2, 10-0 ACC), who are first in the league, are 12-0 on their home court this season.

Tip-off from Cameron Indoor Stadium in Durham, NC, is set for 6:30 p.m. ET. Duke is a 14-point favorite in the latest North Carolina vs. Duke odds from SportsLine consensus, while the over/under for total points scored is 148.5. The Blue Devils are -1190 favorites on the money line (risk $1,190 to win $100).

Before making any North Carolina vs. Duke picks, check out the college basketball predictions from the SportsLine Projection Model.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 13 of the 2024-25 season on a 202-142 betting roll (+2468) on all top-rated college basketball picks dating back to 2023. Anyone following at sportsbooks and on betting apps could have seen huge returns.

The model has simulated North Carolina vs. Duke 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 50% of simulations!

So who wins North Carolina vs. Duke, and which side of the spread hits over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks!