The ninth-ranked Illinois Fighting Illini battle the No. 19 Indiana Hoosiers in a Big Ten Conference opener for both teams on Saturday night. Illinois is coming off a 38-0 win over Western Michigan, while Indiana buried Indiana State 73-0 in Week 3. The Fighting Illini (3-0), who finished in a tie with Iowa for fifth in the Big Ten at 6-3 and were 10-3 overall last season, are 3-2 on the road over the past two years. The Hoosiers (3-0), who tied with Penn State for second in the conference at 8-1 and were 11-2 overall, are 11-0 at home since the start of 2024.

Kickoff from Memorial Stadium in Bloomington, Ind., is at 7:30 p.m. ET. Illinois leads the all-time series 46-25-3, including a 48-45 win in their last meeting in 2023. The Hoosiers are 7-point favorites in the latest Illinois vs. Indiana odds, while the over/under for total points scored is 51.5 via SportsLine consensus. 

Before making any Illinois vs. Indiana picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 32-20 combined on money-line and over/under picks since the beginning of 2024. Anyone following at sportsbooks and on betting apps could have seen STRONG returns!

The model has simulated Illinois vs. Indiana 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in well over 50% of simulations!

So who wins Illinois vs. Indiana, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!