No. 9 Clemson vs. Duke odds, line, picks: Advanced computer model reveals predictions for Monday's ACC college football game

The ninth-ranked Clemson Tigers head to Durham, N.C. on Monday night to face the Duke Blue Devils as the teams open their 2023 college football seasons. The Tigers kicked off with a victory against Georgia Tech on Labor Day last season on their way to an 11-3 season and their seventh ACC title in eight years. The Blue Devils return 19 starters from a team that went a surprising 9-4 after winning five games the previous two seasons combined.   

Kickoff is set for 8 p.m. ET at Wallace Wade Stadium. The Tigers are 12.5-point favorites in the latest Clemson vs. Duke odds, according to the SportsLine consensus, and the over/under for total points scored is 54.5.

Before you make any Duke vs. Clemson picks or college football predictions, you NEED to see the predictions from the SportsLine Projection Model.

The model simulates every FBS college football game 10,000 times. Since its inception, the proprietary computer model has generated a stunning profit of almost $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows the Tigers are perennial national playoff contenders and expect to be again. Star running back Will Shipley, who averaged 125 total yards per game and had 13 rushing touchdowns, will be a focal point on offense. Quarterback Cade Klubnik averaged 340 total yards over the final two games -- a 39-10 ACC Championship victory against North Carolina and a 31-14 loss to Tennessee in the Orange Bowl. 

The model also has taken into account that the Blue Devils have a ton of confidence after a nine-win season that ended with a 30-13 Military Bowl victory against UCF. Almost everyone is back, including dual-threat quarterback Riley Leonard. He led the team with 699 rushing yards and scored 13 touchdowns on the ground in 2022 and threw for 2,967 and 20 more TDs. Receiver Jalon Calhoun and former quarterback Jordan Moore combined for 122 catches, 1,529 yards and nine TDs. 

Now, the model has set its sights on Monday night's Clemson vs. Duke matchup. We can tell you it is leaning Under on the total, and it also says one side of the spread hits in well over 50% of simulations! You ABSOLUTELY need to see it before locking in any college football picks!

Who wins Duke vs. Clemson on Monday night, and which side of the spread hits in well over 50% of simulations? ... Join SportsLine right now to find out which side of the Clemson vs. Duke spread you should be all over Monday, all from the model that's up nearly $2,500 on top-rated CFB spread picks!