No. 6 Oregon vs. No. 3 Penn State odds, line: 2025 college football picks for Week 5 predictions from proven expert

Big Ten behemoths clash when the sixth-ranked Oregon Ducks meet the third-ranked Penn State Nittany Lions on Saturday night. The Ducks (4-0, 1-0 Big Ten), who won the conference regular-season title a year ago, are 6-0 on the road since the beginning of 2024. The Nittany Lions (3-0, 0-0 Big Ten), who tied for second in the conference at 8-1 and were 13-3 overall last season, are 10-1 on their home field since the start of 2024.

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Kickoff from Beaver Stadium in University Park, Pa., is at 7:30 p.m. ET. Penn State leads the all-time series 3-2, but Oregon earned a 45-37 win in last year's Big Ten Championship Game. The Nittany Lions are 3.5-point favorites in the latest Oregon vs. Penn State odds, while the over/under for total points scored is 53.5 via SportsLine consensus. Penn State is the -174 favorite on the money line.

Before making any Oregon vs. Penn State picks, be sure to check out what SportsLine expert Adam Silverstein has to say.

CBS Sports' managing editor, Silverstein is an expert on college and pro football and is coming off a second straight dominant NFL season. He went 100-75-7 (plus $1,749 for $100 players, every bet one unit) in the 2024 season, bringing his two-year run to 188-138-16 (plus $3,564). He especially has the pulse of Penn State football. In his last 19 selections involving the Nittany Lions, he is 17-2 (+1475)!

For Penn State vs. Oregon, Silverstein is leaning Under on the total, and he's also found a crucial X-factor makes one side of the spread a MUST-BACK! 

Who wins Oregon vs. Penn State, and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the spread to jump on, all from the expert who is on a huge 17-2 run on Penn State picks!

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