No. 6 Oklahoma vs. Kansas State lines, odds: Advanced computer model makes spread pick for Saturday's showdown

No. 6 Oklahoma is 4-0 in 2021 and will look to remain undefeated in a Big 12 matchup against Kansas State on Saturday at Bill Snyder Family Stadium. The Sooners are 12.5-point favorites in the latest Oklahoma vs. Kansas State odds at Caesars Sportsbook. The Over-Under is set at 53. Kickoff is set for 3:30 p.m. ET. (See the latest college football lines for all of this week's games on our college football odds page.)

Before you make any Oklahoma vs. Kansas State picks, you'll want to see the college football predictions from the SportsLine Projection Model.  

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,300 for $100 players on its top-rated college football picks against the spread. After going a sizzling 9-3 in Week 4, It also enters Week 5 of the 2021 season on an 81-61 run on all top-run.

The model knows that Spencer Rattler is playing at a high level for the Sooners. The Oklahoma signal-caller ranks 11th in total passes thrown with 135 and is sixth in completion percentage (74.1). He's racked up 1,117 passing yards to go along with eight passing touchdowns for one of the country's top scoring offenses.

The model also knows that the Wildcats' ground game is strong. Deuce Vaughn has rushed for 393 yards and five touchdowns and is averaging 5.2 yards per carry. However, he'll face an Oklahoma defense that hasn't given up more than 50 yards on the ground to any running back this season.

Now the model has simulated Oklahoma vs. Kansas State 10,000 times, and the results are in. We can tell you that the model is leaning Over on the total, and it has generated a point-spread pick that is hitting in over 60 percent of simulations. You absolutely need to see it before locking in your own picks.

Who wins the battle between Oklahoma and Kansas State? And which side of the spread hits in over 60 percent of simulations? ... Join SportsLine right now to see which side of the Oklahoma vs. Kansas State spread you need to jump on Saturday, all from the computer model that has crushed its college football picks!