No. 5 Tennessee vs. Missouri odds, line: Advanced college football computer model reveals picks for Saturday's SEC matchup

The No. 5 Tennessee Volunteers attempt to bounce back from their first loss of the season when they host the Missouri Tigers in an SEC matchup on Saturday. Tennessee (8-1, 4-1 SEC) was the top-ranked team in the nation before suffering a 27-13 setback at Georgia last weekend. Missouri (4-5, 2-4) also is coming off a loss as it dropped a 21-17 decision to Kentucky at home last Saturday.

Kickoff at Neyland Stadium in Knoxville is set for noon ET. The Volunteers are 19.5-point favorites in the latest Tennessee vs. Missouri odds from Caesars Sportsbook, while the over/under for total points scored is 57. Saturday's game can be seen live on CBS and streamed live on Paramount+ with their must-have Premium plan. 

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Before making any Missouri vs. Tennessee picks or college football predictions, you NEED to see the predictions from the SportsLine Projection Model.

The model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows Tennessee is 6-0 at home and is looking to finish with a perfect record at Neyland Stadium for the first time since 2007. The Volunteers have won eight consecutive home games, their longest such streak since capturing nine in a row from 2006-08. Tennessee has outscored its opponents 321-128 in Knoxville this year, recording at least 38 points in each contest and notching 50 or more on four occasions.

The model also knows Missouri has played well defensively this season despite its losing record. The Tigers are fourth in the SEC in total defense (304.1 yards) and points allowed (21.4) and rank third in yards allowed per play (4.8). Missouri leads the conference and is tied for 10th in the nation with 67 tackles for loss and is fourth in the SEC with 22 sacks.

Now, the model has set its sights on Tennessee vs. Missouri. We can tell you it is leaning Over on the total, and it also says one side of the spread hits well over 50% of the time! You ABSOLUTELY need to see it before locking in any college football picks, and don't forget to stream this game on Paramount+!

Who wins Tennessee vs. Missouri? And which side of the spread hits well over 50% of the time? ... Join SportsLine right now to find out which side of the Missouri vs. Tennessee spread you should be all over on Saturday, all from the model on a roll on college football picks!