No. 4 Duke vs. No. 7 Michigan State odds, prediction: 2025 men's college basketball picks from proven model

The fourth-ranked Duke Blue Devils battle the seventh-ranked Michigan State Spartans in a battle of unbeatens on Saturday. Duke is coming off a 67-66 win over 15th-ranked Florida on Tuesday, while Michigan State downed Iowa 71-52 that same night. The Blue Devils (9-0), who are 3-0 against ranked opponents, are 1-0 on the road this season. The Spartans (8-0), who are 3-0 against ranked foes, are 5-0 on their home floor in 2025-26.

Tip-off from the Breslin Center in East Lansing, Mich., is set for noon ET. Duke leads the all-time series 15-4, including wins in each of the last two meetings. Duke is a 1.5-point favorite in the latest Duke vs. Michigan State odds from SportsLine consensus, while the over/under for total points scored is 140.5.

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Before making any Duke vs. Michigan State picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and has returned over $2,000 in betting profit for $100 players on its top-rated college basketball picks over the past three-plus seasons. Anyone following could have seen HUGE returns!

The model has simulated Duke vs. Michigan State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in over 70% of simulations!

So who wins Duke vs. Michigan State, and which side hits over 70% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!

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