The fourth-ranked Duke Blue Devils battle the seventh-ranked Michigan State Spartans in a battle of unbeatens on Saturday. Duke is coming off a 67-66 win over 15th-ranked Florida on Tuesday, while Michigan State downed Iowa 71-52 that same night. The Blue Devils (9-0), who are 3-0 against ranked opponents, are 1-0 on the road this season. The Spartans (8-0), who are 3-0 against ranked foes, are 5-0 on their home floor in 2025-26.

Tip-off from the Breslin Center in East Lansing, Mich., is set for noon ET. Duke leads the all-time series 15-4, including wins in each of the last two meetings. Michigan State is a 1.5-point favorite in the latest Duke vs. Michigan State odds from SportsLine consensus, while the over/under for total points scored is 138.5.

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Before making any Duke vs. Michigan State picks, check out the college basketball predictions from the SportsLine Projection Model.

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The model has simulated Duke vs. Michigan State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in nearly 80% of simulations!

So who wins Duke vs. Michigan State, and which side hits nearly 80% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!

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