No. 4 Alabama vs. South Carolina odds, line: 2025 college football picks for Week 9 predictions from proven model

The fourth-ranked Alabama Crimson Tide will look to stay unbeaten in Southeastern Conference action when they take on the South Carolina Gamecocks on Saturday. Alabama is coming off a 37-20 win over Tennessee in Week 8, while South Carolina was beaten 26-7 by Oklahoma. The Crimson Tide (6-1, 4-0 SEC), who have won six in a row, are 2-1 on the road this season. The Gamecocks (3-4, 1-4 SEC), who have lost two straight, are 2-2 on their home field in 2025.

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Kickoff from Williams-Brice Stadium in Columbia, S.C., is at 3:30 p.m. ET. Alabama leads the all-time series 14-3, including a 4-2 edge in Columbia. The Crimson Tide are 11.5-point favorites in the latest Alabama vs. South Carolina odds, while the over/under for total points scored is 47.5 via SportsLine consensus. 

Before making any Alabama vs. South Carolina picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 42-30 combined on money-line and over/under picks since the beginning of 2024. Anyone following at sportsbooks and on betting apps could have seen STRONG returns!

The model has simulated Alabama vs. South Carolina 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in well over 50% of simulations!

So who wins Alabama vs. South Carolina, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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