No. 3 Florida vs. No. 13 Arizona odds, prediction: 2025 NCAA Hall of Fame Series picks from proven model

The defending national champion and third-ranked Florida Gators open their 2025-26 men's college basketball season against the 13th-ranked Arizona Wildcats on Monday night in a Hall of Fame Series matchup. Florida is coming off their third-ever national championship, while Arizona is in pursuit of its first since 1997. The Gators, who finished 36-4 a year ago, placed second in the Southeastern Conference at 14-4, one game behind Auburn. The Wildcats, meanwhile, who tied for third at 14-6 in the Big 12, were 24-13 overall in 2024-25.

Tipoff from the T-Mobile Arena in Las Vegas is set for 7 p.m. ET. The all-time series is tied 2-2, with Arizona winning the last meeting 65-64 on Dec. 15, 2012. Florida is a 3.5-point favorite in the latest Florida vs. Arizona odds from SportsLine consensus, while the over/under for total points scored is 164.5.

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Before making any Florida vs. Arizona picks, check out the college basketball predictions from the SportsLine Projection Model.

SportsLine's model simulates every college basketball game 10,000 times, and is coming off a profitable 75-61 season on top-rated college basketball picks!

The model has simulated Florida vs. Arizona 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits over 50% of the time!

So who wins Florida vs. Arizona, and which side of the spread hits over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is coming off a profitable year on top-ranked picks!

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