No. 25 Memphis vs. Rice odds, line: 2025 college football picks for Week 10 predictions from proven model

The 25th-ranked Memphis Tigers will look to stay in the mix for an American Conference championship when they take on the Rice Owls in a key conference matchup on Friday night. Memphis is coming off a 34-31 win over South Florida, while Rice downed Connecticut 37-34 in double overtime this past Saturday. The Tigers (7-1, 3-1 American), who are tied for third in the league, are 3-1 on the road this season. The Owls (4-4, 1-3 American), who are tied for 11th, are 2-2 on their home field in 2025.

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Kickoff from Rice Stadium in Houston is at 7 p.m. ET. Memphis leads the all-time series 3-2, after beating Rice 27-20 last season. The Tigers are 14-point favorites in the latest Memphis vs. Rice odds, while the over/under for total points scored is 48.5 via SportsLine consensus.  

Before making any Memphis vs. Rice picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks, and it enters Week 10 on a profitable 47-33 combined run on money-line and over/under picks since the beginning of 2024. Anyone following could have seen impressive returns.

The model has simulated Memphis vs. Rice 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in well over 50% of simulations.

So who wins Memphis vs. Rice, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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