Two of the top teams in the American Conference clash when the 24th-ranked South Florida Bulls meet the North Texas Mean Green on Friday night. South Florida is coming off a 54-26 win over Charlotte on Oct. 3, while North Texas downed South Alabama 36-22 on Sept. 27. The Bulls (4-1, 1-0 American), who have won two in a row, are 1-1 on the road this season. The Mean Green (5-0, 1-0 American), who have outscored their opponents 224-100, are 3-0 on their home field in 2025.

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Kickoff from DATCU Stadium in Denton, Texas, is at 7:30 p.m. ET. South Florida leads the all-time series 2-0. The Mean Green are 2.5-point favorites in the latest South Florida vs. North Texas odds, while the over/under for total points scored is 67.5 via SportsLine consensus. 

Before making any South Florida vs. North Texas picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 38-25 combined on money-line and over/under picks since the beginning of 2024. Anyone following at sportsbooks and on betting apps could have seen STRONG returns!

The model has simulated South Florida vs. North Texas 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in well over 60% of simulations!

So who wins South Florida vs. North Texas, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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