No. 21 Michigan vs. Northwestern odds, line: 2025 college football picks for Week 12 predictions from proven model

The 21st-ranked Michigan Wolverines will look to keep their Big Ten championship hopes alive when they take on the Northwestern Wildcats in a key conference matchup on Saturday. Michigan is coming off a 21-16 win over Purdue on Nov. 1, while Northwestern dropped a 38-17 decision at USC last Friday. The Wolverines (7-2, 5-1 Big Ten), who are tied for third in the conference with USC and Oregon, are just 2-2 on the road this season. The Wildcats (5-4, 3-3 Big Ten), who are tied for ninth in the league, are 4-1 on their home field in 2025.

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Kickoff from Wrigley Field in Chicago is at noon ET. Michigan leads the all-time series 60-15-2, including eight in a row. The Wolverines are 10.5-point favorites in the latest Michigan vs. Northwestern odds, while the over/under for total points scored is 41.5 via SportsLine consensus. 

Before making any Michigan vs. Northwestern picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks. Anyone following could have seen impressive returns.

The model has simulated Michigan vs. Northwestern 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits well over 50% of the time!

So who wins Michigan vs. Northwestern, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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