No. 20 Tulane vs. No. 6 Ole Miss odds, line: 2025 College Football Playoff first-round matchup picks from proven model

The 20th-ranked Tulane Green Wave will take on the sixth-ranked Ole Miss Rebels in a College Football Playoff first-round matchup on Saturday. Tulane won the American Conference championship with a 34-21 win over North Texas on Dec. 5, while Ole Miss finished the regular season with a 38-19 win at Mississippi State. The Green Wave (11-2), who finished 7-1 in the American, are 2-1 against ranked opponents this season. The Rebels (11-1), who finished tied for first in the Southeastern Conference at 7-1, are 2-1 against ranked foes in 2025. Jon Sumrall has taken the coaching job at Florida, but will coach the Green Wave until their season comes to an end. Former Ole Miss coach Lane Kiffin, however, has already left for LSU.

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Kickoff from Vaught-Hemingway Stadium in Oxford, Miss., is at 3:30 p.m. ET. Ole Miss leads the all-tme series 46-28, including a 45-10 win on Sept. 20. The Rebels are 17.5-point favorites in the latest Tulane vs. Ole Miss odds, while the over/under for total points scored is 56.5 via SportsLine consensus. 

Before making any Tulane vs. Ole Miss picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times, and it is profitable on its top-rated money-line picks since the beginning of the 2024 season. Anyone following could have seen impressive returns.

The model has simulated Tulane vs. Ole Miss 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits well over 50% of simulations!

So who wins Tulane vs. Ole Miss, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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