No. 2 Indiana vs. Penn State odds, line: 2025 college football picks for Week 11 predictions from proven model

The second-ranked Indiana Hoosiers will look to keep the Penn State Nittany Lions winless in Big Ten Conference play when they meet on Saturday. Indiana is coming off a 55-10 win over Maryland, while Penn State dropped a 38-14 decision at Ohio State. The Hoosiers (9-0, 6-0 Big Ten), who lead the conference, are 3-0 on the road this season. The Nittany Lions (3-5, 0-5 Big Ten), who have lost five in a row, are 3-2 on their home field this year. Indiana senior wide receiver Elijah Sarratt (hamstring) is questionable after missing last week's game.

LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month at SportsLine for $1 JOIN NOW. 

Kickoff from Beaver Stadium in University Park, Pa., is at noon ET. Penn State leads the all-time series 25-2, including a 33-24 win in the last meeting in 2023. The Hoosiers are 14.5-point favorites in the latest Indiana vs. Penn State odds, while the over/under for total points scored is 49.5 via SportsLine consensus. 

Before making any Indiana vs. Penn State picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks. Anyone following could have seen impressive returns.

The model has simulated Indiana vs. Penn State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in well over 60% of simulations.

So who wins Indiana vs. Penn State, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month at SportsLine for $1 JOIN NOW.