No. 19 Kansas vs. No. 25 North Carolina odds, prediction: 2025 NCAA men's basketball picks from proven model

A pair of blue blood programs clash when the 19th-ranked Kansas Jayhawks face the No. 25 North Carolina Tar Heels on Friday night. Kansas opened its season with a 94-51 thrashing of Green Bay, while North Carolina cruised past Central Arkansas 94-54. The Jayhawks (1-0), who finished sixth in the Big 12 last season at 11-9 and were 21-13 overall, were 4-4 against ranked opponents a year ago. The Tar Heels (1-0), who tied for fourth in the ACC at 13-7 and were 23-14 overall, were just 1-8 against ranked foes in 2024-25.

Tip-off from the Dean E. Smith Center in Chapel Hill, N.C., is set for 7 p.m. ET. The Jayhawks lead the all-time series 7-6, including a 92-89 win in Kansas last year. North Carolina is a 2.5-point favorite in the latest Kansas vs. North Carolina odds from SportsLine consensus, while the over/under for total points scored is 158.5.

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Before making any Kansas vs. North Carolina picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and has returned over $2,200 in betting profit for $100 players on its top-rated college basketball picks over the past three seasons. Anyone following could have seen HUGE returns!

The model has simulated Kansas vs. North Carolina 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread is the better value!

So who wins Kansas vs. North Carolina, and which side of the spread is the better value time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is coming off a profitable year on top-ranked picks!

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