No. 17 Arizona vs. SMU odds, line: 2026 college football picks for Holiday Bowl matchup from proven model

The 17th-ranked Arizona Wildcats battle the SMU Mustangs in the 2026 Holiday Bowl on Friday night. Arizona is coming off a 23-7 win at Arizona State on Nov. 28, while SMU is coming off a 38-35 loss at California on Nov. 29. The Wildcats (9-3), who finished tied for fourth at 6-3 in the Big 12, have won five in a row. The Mustangs (8-4), who tied for second in the ACC at 6-2, are 1-0 against ranked teams this season. 

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Kickoff from Snapdragon Stadium in San Diego is at 8 p.m. ET. The all-time series is tied 1-1, with Arizona winning 28-6 in the last meeting in 1985. The Mustangs are 1.5-point favorites in the latest Arizona vs. SMU odds, while the over/under for total points scored is 51.5 via SportsLine consensus. SMU is the -113 favorite on the money line. 

Before making any Arizona vs. SMU picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times, and it is 31-19 on rated college football money-line picks since the beginning of the 2024 season. 

The model has simulated Arizona vs. SMU 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread is the better value!

So who wins Arizona vs. SMU, and which side of the spread is the better value? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!

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