The No. 16 Syracuse Orange will try to bounce back from their first loss of the season when they host the Notre Dame Fighting Irish on Saturday at the JMA Wireless Dome in Syracuse, N.Y. The Orange (6-1) have won six games in a season for the first time since 2018 when they went 10-3. They are coming off a 27-21 loss at No. 5 Clemson in which they led by 11 points in the fourth quarter. Meanwhile the Fighting Irish (4-3) are on track to have their worst season since going 4-8 in 2016. 

Kickoff is noon ET. The Orange are 1.5-point favorites in the latest Syracuse vs. Notre Dame odds from Caesars Sportsbook, while the over/under for total points scored is 47.5. (See up-to-date odds for every game this week on our college football odds page.)

Before making any Notre Dame vs. Syracuse picks or college football predictions, you NEED to see the predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

The model knows that Syracuse has one of the best defenses in the country. The Orange rank sixth in the nation in scoring defense, allowing 15.1 points per game. They are keeping their opponents out of the end zone at a pace that hasn't been achieved in the past 25 years.

The model also knows that Notre Dame has one of the best tight ends in the country in Michael Mayer. The 6-foot-4, 265-pound junior ranks 22nd in the country in receiving touchdowns (six) and also leads the team in receiving yards per game (75.1). Already the all-time leader in tight end receptions at Notre Dame (157), Mayer needs one more touchdown to sit alone atop the tight end career touchdown list.

Now, the model has set its sights on Syracuse vs. Notre Dame. We can tell you it is leaning Under the total, and it also says one side of the spread hits in more than 50% of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Notre Dame vs. Syracuse? And which side of the spread hits in more than 50% of simulations? ... Join SportsLine right now to find out which side of the Syracuse vs. Notre Dame spread you should be all over Saturday, all from the model on a roll on college football picks!