No. 15 St. John's vs. No. 6 UConn odds, prediction: 2026 Big East Conference men's college basketball picks from proven model

First place in the Big East Conference will be on the line when the 15th-ranked St. John's Red Storm takes on the sixth-ranked Connecticut Huskies on Wednesday. St. John's is coming off an 81-52 win over Creighton on Saturday, while UConn earned a 73-63 win at Villanova that same day. The Red Storm (22-5, 15-1 Big East), who have won 13 in a row, are 8-0 on the road this season. The Huskies (25-3, 15-2 Big East), who have won three of five, are 13-2 on their home floor.

Tip-off from PeoplesBank Arena in Hartford, Conn., is set for 7 p.m. ET. St. John's leads the all-time series 40-34, including an 81-72 decision on Feb. 6. UConn is a 4.5-point favorite in the latest St. John's vs. UConn odds from DraftKings Sportsbook, while the over/under for total points scored is 146.5. 

Before making any St. John's vs. UConn picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 17 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 20-11 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated St. John's vs. UConn 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits well over 60% of the time!

So who wins St. John's vs. UConn, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!