The Clemson Tigers will try to pull the upset Saturday when they host the 15th-ranked Notre Dame Fighting Irish at Memorial Stadium in a college football Week 10 matchup. The Irish (7-2) crushed Pitt 58-7 last Saturday following a rout of then-10th-ranked USC the previous week. The Tigers (4-4, 2-4 ACC) have lost consecutive games, falling to NC State after a loss to Miami in overtime. 

Saturday's kickoff is set for noon ET in Clemson, S.C. The latest Notre Dame vs. Clemson odds list the Irish as 3.5-point favorites, according to the SportsLine consensus, while the over/under for total points scored is 44 (Head to SportsLine's college football odds page for the latest odds on every game).

Before you make any Clemson vs. Notre Dame picks or college football Week 10 predictions, you NEED to see the predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows the Irish have only lost to Ohio State and Louisville, both current top-15 teams. They have one of the nation's best defenses, a unit that allows 15.3 points per game (10th in FBS) and has 18 takeaways. Quarterback Sam Hartman (2,126 passing yards) runs an offense that averages 428 yards and ranks 10th in the nation at 7 yards per play.

The model also has considered that the Tigers' defense is still formidable, yielding just 267 total yards, sixth-fewest in the nation. It is particularly strong against the run, giving up 99 yards (16th) and allows just 4.3 yards per play overall (eighth). Running backs Will Shipley and Phil Mafah have combined for 954 rushing yards, and Mafah has scored six touchdowns.

Now, the model has set its sights on Saturday's Notre Dame vs. Clemson matchup. We can tell you it is leaning Over on the total, and it also says one side of the spread is hitting in well over 50% of simulations! You ABSOLUTELY need to see it before locking in any college football picks!

Who wins the Notre Dame vs. Clemson matchup on Saturday, and which side of the spread hits well over 50% of the time? ... Join SportsLine right now to find out which side of the Clemson vs. Notre Dame spread you should be all over Saturday, all from the model that's up well over $2,000 on top-rated CFB spread picks!