No. 13 Michigan State vs. No. 8 Purdue odds, prediction: 2026 Big Ten Conference men's college basketball picks from proven model

The 13th-ranked Michigan State Spartans meet the eighth-seeded Purdue Boilermakers on Thursday night in a battle for seeding for the upcoming Big Ten Conference Tournament. Michigan State is coming off a 66-60 win over Ohio State on Sunday, while Purdue downed Indiana 93-64 on Friday. The Spartans (22-5, 12-4 Big Ten), who are 4-3 against ranked opponents, are 4-3 on the road this season. The Boilermakers (22-5, 12-4 Big Ten), who are also 4-3 against ranked foes, are 12-3 on their home court.

Tip-off from Mackey Arena in West Lafayette, Ind., is set for 8 p.m. ET. Purdue leads the all-time series 77-57, including a 47-18 edge in games played at West Lafayette. Purdue is a 5.5-point favorite in the latest Michigan State vs. Purdue odds from DraftKings Sportsbook, while the over/under for total points scored is 139.5. 

Before making any Michigan State vs. Purdue picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 17 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 20-11 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Michigan State vs. Purdue 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits over 50% of the time!

So who wins Michigan State vs. Purdue, and which side of the spread hits over 50% the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!