The No. 10 USC Trojans (1-0) and the Stanford Cardinals (1-0) match up for a conference battle on Saturday evening at 7:30 p.m. ET. USC is favored by 9.5 points at Caesars Sportsbook, while the over/under is set at 65 (see up-to-date odds for every game this week on our college football odds page). 

Before making any USC vs. Stanford picks, you NEED to check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It enters Week 2 of the 2022 college football season on a 48-37 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

The model knows USC sophomore quarterback Caleb Williams is an impact player. Williams owns a strong arm with terrific quickness and agility to make plays with his legs. He has the ability to make plays outside of the pocket which is always an asset for the offense. In the season opener, Williams was extremely efficient. He went 19-for-22 for 249 yards with two passing touchdowns. 

The model also knows Stanford junior quarterback Tanner McKee is an impressive signal caller. McKee has solid accuracy and arm talent to spray the ball all across the yard. The California native generates plenty of velocity on his throws. In the season-opening win over Colgate, McKee went 22-for-27 for 308 yards and two passing touchdowns. 

Now, it has set its sights on USC vs. Stanford. We can tell you the model is leaning Over the total, and it also says one side of the spread hits in well over 70% of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

So who wins USC vs. Stanford? And which side of the spread hits well over 70% of the time? Join SportsLine now to find out, all from the model that has crushed its top-rated college football picks against the spread!