No. 10 Notre Dame vs. No. 24 Pittsburgh odds, line: 2025 college football picks for Week 12 predictions from proven model

The 10th-ranked Notre Dame Fighting Irish battle the 24th-ranked Pittsburgh Panthers in a key non-conference matchup on Saturday afternoon. Notre Dame is coming off a 49-10 win over Navy last Saturday, while Pittsburgh downed Stanford 35-20 on Nov. 1. The Fighting Irish (7-2), who have won seven in a row, are 2-1 on the road this season. The Panthers (7-2), who are tied for the Atlantic Coast Conference lead at 5-1, have won five in a row and are 4-1 on their home field.

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Kickoff from Acrisure Stadium in Pittsburgh is at noon ET. Notre Dame leads the all-time series 51-21-1, including a 28-11-1 edge in games played in Pittsburgh. The Fighting Irish are 12.5-point favorites in the latest Notre Dame vs. Pittsburgh odds, while the over/under for total points scored is 54.5 via SportsLine consensus. 

Before making any Notre Dame vs. Pittsburgh picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks. Anyone following could have seen impressive returns.

The model has simulated Notre Dame vs. Pittsburgh 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in nearly 70% of simulations.

So who wins Notre Dame vs. Pittsburgh, and which side of the spread hits nearly 70% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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