No. 1 Ohio State vs. No. 18 Michigan odds, line: 2025 college football picks for Week 14 predictions from proven model

The top-ranked Ohio State Buckeyes look to snap a four-game losing streak in the series when they battle the 18th-ranked Michigan Wolverines in a key Big Ten Conference matchup on Saturday. Ohio State will also look to secure a spot in the Big Ten Conference Championship Game with a win, while Michigan could do the same, but will need some help. The Buckeyes (11-0, 8-0 Big Ten), the defending national champions, have not beaten Michigan since 2019. The Wolverines (9-2, 7-1 Big Ten), who are tied for third in the conference with Oregon, are 5-0 on their home field. Ohio State lists receivers Carnell Tate and Jeremiah Smith as questionable.

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Kickoff from Michigan Stadium in Ann Arbor, Mich., is at noon ET. Michigan leads the all-time series 62-52-6. The Buckeyes are 10-point favorites in the latest Ohio State vs. Michigan odds, while the over/under for total points scored is 43.5 via SportsLine consensus. 

Before making any Ohio State vs. Michigan picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times, and it is profitable on its top-rated money-line and over/under picks since the beginning of the 2024 season. Anyone following could have seen impressive returns.

The model has simulated Ohio State vs. Michigan 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in well over 50% of simulations!

So who wins Ohio State vs. Michigan, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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