No. 1 Duke vs. Notre Dame odds, prediction: 2026 Atlantic Coast Conference men's college basketball picks from proven model

The top-ranked Duke Blue Devils look to stay in first place in the Atlantic Coast Conference when they battle the Notre Dame Fighting Irish in a key matchup on Tuesday night. Duke is coming off a 68-63 win over Michigan on Saturday, while Notre Dame dropped a 73-68 decision at Pittsburgh that same day. The Blue Devils (25-2, 13-1 ACC), who have won four in a row, are 8-1 on the road this season. The Fighting Irish (12-15, 3-11 ACC), who are 0-4 against ranked opponents, are 9-5 on their home floor.

Tip-off from Purcell Pavilion in Notre Dame, Ind., is set for 7 p.m. ET. Duke leads the all-time series 32-8, including 9-4 at Purcell Pavilion. Duke is a 17.5-point favorite in the latest Duke vs. Notre Dame odds from DraftKings Sportsbook, while the over/under for total points scored is 138.5. 

Before making any Duke vs. Notre Dame picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 17 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 20-11 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Duke vs. Notre Dame 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits well over 50% of the time!

So who wins Duke vs. Notre Dame, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!