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NFL Week 8 odds, score predictions: SportsLine AI reveals picks for every game

SportsLine AI reveals its NFL picks against the spread, over/under and money line for every NFL game in Week 8

ByPublished: Oct 26, 2025 2:45PM UTC . 3 min read

Aaron Rodgers spent the first 18 years of his future Hall of Fame career with the Green Bay Packers. His career comes full circle in NFL Week 8 when his Pittsburgh Steelers take on the Packers in Pittsburgh. It will be the first time he has faced the team that drafted him in the first round of the 2005 NFL Draft. The Packers (4-1-1) lead the NFC North, while the Steelers (4-2) are on top of the AFC North. Green Bay enters as a 3-point favorite and is one of three road favorites during the Week 8 NFL schedule. 

Another matchup involving contenders sees the Buffalo Bills (4-2) visiting the Carolina Panthers (4-3). The Bills are -7 favorites, one of five games with spreads of -7 or more as Andy Dalton will start in place of Bryce Young. The largest is Tennessee at Indianapolis (-14.5), followed by Chiefs (-11.5) vs. Commanders, with Washington, which will be without Jayden Daniels (hamstring), looking to end an eight-game losing streak to Kansas City

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Before making any Week 8 NFL picks, be sure to check out the NFL score predictions from the SportsLine's self-learning AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data then quantitatively evaluating the strength of the opponents defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see a 5-star rating on an Over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine's AI has nailed more than 2,000 4.5- and 5-star prop picks since the start of the 2023 season! Anyone who has followed it is WAY UP!

After analyzing every game in Week 8, the AI says the Colts (-14.5, 48), who have Daniel Jones at quarterback, cover comfortably against the Titans. Jones has been on fire. In seven starts, he has completed 71% of his passes for 1,790 yards and 10 touchdowns with three interceptions. SportsLine AI rates a Colts spread cover as an A pick and also predicts a 36-18 win on average.

SportsLine AI has generated against the spread, over/under and money-line picks for every game in Week 8! In fact, the AI has generated well over 20 HIGHLY-COVETED A+ picks! You ABSOLUTELY NEED to see the AI analysis before making any Week 8 NFL bets.

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Daniel Kohn

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