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NFL Week 7 odds, score predictions: SportsLine AI reveals picks for every game

SportsLine AI reveals its NFL picks against the spread, over/under and money line for every NFL game in Week 7

ByPublished: Oct 19, 2025 2:23PM UTC . 3 min read

The AFC West race heats up in Week 7 with several key battles, including a matchup between longtime bitter rivals when the Kansas City Chiefs take on the Las Vegas Raiders at Kansas City. The Chiefs (3-3), who are third in the division, are just one game out of first place. The Chiefs have won the division in each of the past nine seasons. Other AFC West teams in action include the Denver Broncos (4-2), who play the New York Giants (2-4) at Denver, and the Los Angeles Chargers (4-2), who play the AFC South-leading Indianapolis Colts (5-1) in Los Angeles. The Broncos are -7.5 and the Chargers are -2.5 in their respective matchups. The Chiefs are 11.5-point favorites over the Raiders (2-4) in the largest of the Week 7 NFL spreads and one of three of at least a touchdown.

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Before making any Week 7 NFL picks, be sure to check out the NFL score predictions from the SportsLine's self-learning AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data then quantitatively evaluating the strength of the opponents defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see a 5-star rating on an Over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine's AI has nailed more than 2,000 4.5- and 5-star prop picks since the start of the 2023 season! Anyone who has followed it is WAY UP!

After analyzing every game in Week 7, the AI says the Chiefs (-11.5, 45.5), who have Rashee Rice back from suspension, cover comfortably against the Raiders. Kansas City quarterback Patrick Mahomes has been dominant completing 64.8% of his passes for 1,514 yards and 11 touchdowns with just two interceptions. In the 30-17 win over the Detroit Lions, Mahomes completed 22 of 30 passes (73.3%) for 257 yards and three touchdowns. SportsLine AI rates a Chiefs cover as an B pick and also predicts a 31-17 win on average.

SportsLine AI has generated against the spread, over/under and money-line picks for every game in Week 7! In fact, the AI has generated well over 30 HIGHLY-COVETED A+ picks! You ABSOLUTELY NEED to see the AI analysis before making any Week 7 NFL bets.

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Daniel Kohn

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