The Pittsburgh Steelers will look to build on their lead in the AFC North when they take on the visiting Cleveland Browns in a key Week 6 matchup. The Steelers enter with a 3-1 mark, while the 1-4 Browns will be out to snap a two-game losing streak. Other AFC North teams in action include the Ravens (1-4), with Lamar Jackson out, who take on the Los Angeles Rams (3-2), and the Cincinnati Bengals (2-3), who plan on starting Joe Flacco, against the Green Bay Packers (2-1-1) at Lambeau Field. The Steelers are 6-point favorites while the Ravens are 7-point underdogs. Meanwhile, the Bengals are 14.5-point underdogs in a game that has the biggest spread of the 2025 NFL season as Flacco's arrival hasn't shifted this NFL line.

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Before making any Week 6 NFL picks, be sure to check out the NFL score predictions from the SportsLine's self-learning AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data then quantitatively evaluating the strength of the opponents defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see a 5-star rating on an Over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine's AI has nailed more than 2,000 4.5- and 5-star prop picks since the start of the 2023 season! Anyone who has followed it is WAY UP!

After analyzing every game in Week 6, the AI says the Steelers cover comfortably against the Browns. Pittsburgh quarterback Aaron Rodgers is having a solid season, completing 68.5% of his passes for 786 yards and eight touchdowns with just three interceptions. In the 24-21 win over the Minnesota Vikings in Dublin, Ireland, Rodgers completed 18 of 22 passes (81.8%) for 200 yards and one touchdown. AI PickBot rates a Steelers cover as an B pick and also predicts a 25-15 win on average.

SportsLine AI has generated against the spread, over/under and money-line picks for every game in Week 6! In fact, the AI has generated nearly 30 HIGHLY-COVETED A+ picks! You ABSOLUTELY NEED to see the AI analysis before making any Week 6 NFL bets.

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