The Buffalo Bills will look to take control of the AFC East when they take on the 2-2 New England Patriots, who are second in the division, when they meet on Sunday Night Football. Other AFC East teams in action, include the Dolphins (1-3), minus Tyreek Hill, who is out for the season, against the Panthers (1-3) and the Jets (0-4) against the visiting Cowboys (1-2-1), who hope to rebound after a tie on SNF, while the Jets are one of three winless teams left standing. The Bills are 8.5-point favorites, while the Dolphins are 1.5-point favorites, in the slimmest of Week 5 NFL spreads, and the Jets are 2.5-point underdogs.

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Before making any Week 5 NFL picks, be sure to check out the NFL score predictions from the SportsLine's self-learning AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data then quantitatively evaluating the strength of the opponents defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see a 5-star rating on an Over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine's AI has nailed more than 2,000 4.5- and 5-star prop picks since the start of the 2023 season! Anyone who has followed it is WAY UP!

After analyzing every game in Week 5, the AI says the Bills cover comfortably against the Patriots on Sunday Night Football. Josh Allen is coming off a dominant performance in a 31-19 win over the New Orleans Saints last week. He completed 16 of 22 for 209 yards and two touchdowns, while rushing seven times for 45 yards and a score. For the year, he has completed 85 of 121 passes for 964 yards and seven touchdowns with one pick. He also has rushed 31 times for 159 yards and three touchdowns. AI PickBot rates a Bills cover as an A+ pick and also predicts a 34-19 win on average.

SportsLine AI has generated against the spread, over/under and money-line picks for every game in Week 5! In fact, the AI has generated nearly 30 HIGHLY-COVETED A+ picks! You ABSOLUTELY NEED to see the AI analysis before making any Week 5 NFL bets.

Which NFL bets do you need to make NOW for Week 5? And which must-see NFL picks are worthy of an A+ rating? ... Join SportsLine now to see the top 2025 Week 5 NFL picks, all from the self-learning SportsLine AI that has nailed a COLOSSAL 2,000+ top-rated picks since the start of last season!

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