The Week 4 NFL schedule has a number of key matchups, including eight interconference matchups. The season's biggest NFL spread takes place in Saints vs. Bills (-15.5), while other matchups include Browns vs. Lions (-10), Panthers vs. Patriots (-5.5), Chargers vs. Giants (+6.5), Colts vs. Rams (-3.5), Jaguars vs. 49ers (-3) and Bears vs. Raiders (+1.5), which has the slimmest Week 4 NFL line as bettors search for the best opportunities to maximize returns. Point spread, point total, and money-line bets remain staples, and uncovering true value in the Week 4 odds requires a deeper look. 

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Before you make any Week 4 NFL picks, be sure to check out the NFL score predictions from the SportsLine computer simulation model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 39-19 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

After analyzing every game in Week 4, the model says the Commanders beat the Falcons 27-20, comfortably covering as 2.5-point underdogs in a game that goes Over 45.5 total points. 

SportsLine's model has generated against the spread, over/under, and money-line picks for every game in Week 4! In fact, the model has generated two HIGHLY-COVETED A-graded picks! You ABSOLUTELY NEED to see the Model's analysis before making any Week 4 NFL bets.

Which NFL bets do you need to make NOW for Week 4, and which must-see NFL picks are worthy of an A rating? ... Join SportsLine now to see the top 2025 Week 4 NFL picks, all from the SportsLine model that is up well over $7,000 for $100 players on top-rated NFL picks since its inception!

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