The NFL kicks off its 2022 international schedule on Sunday when the Minnesota Vikings and New Orleans Saints collide at Tottenham Hotspur Stadium in London. The Vikings (2-1) and the Saints (1-2) are both 2-0 in games played in London. Sunday's game will be the 100th combined regular season and preseason game played outside of the United States in the history of the NFL. Before you make any Week 4 NFL picks or NFL parlays, you need to see what SportsLine senior analyst Larry Hartstein has to say.

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. He entered the 2022 NFL season 427-344 all-time on NFL side picks (plus $3,764 for $100 players), including 394-330 against the spread. Hartstein went 68-50 ATS and 8-3 on money-line plays last season for a profit of $1,552. His picks are available only at SportsLine and on the Early Edge.

Now, Hartstein has locked in three confident Week 4 NFL best bets. If you successfully parlay his picks, you're looking at a payout of almost 6-1.

We can tell you Hartstein loves the Texans to cover against the Chargers (1 p.m. ET). "Late last season, the Chargers closed as 13.5-point favorites in Houston and lost 41-29," he told SportsLine.

Hartstein also has locked in two other spread picks, including backing a team with a running game that "should excel" on Sunday! You ABSOLUTELY need to see his picks before betting on NFL Week 4.

So what are Hartstein's Week 4 best bets? And which team is a MUST-BACK? ... Join SportsLine right now to see Larry Hartstein's Week 4 NFL best bets, all from the expert who entered the season up more than $3,700!