NFL Week 16 expert spread picks: 49ers among best bets from top NFL expert Larry Hartstein

Warm-weather teams traveling to cold locations is always something to monitor when the calendar flips to December, and this could certainly influence your Week 16 NFL best bets. The Rams will leave sunny L.A. to visit the Jets (+3) on Sunday, while the Saints will leave the humidity of Louisiana for frigid Green Bay (-14.5) on Monday. It's matchups like these in which home-field advantage can really become evident as warm-weather teams can't simulate cold conditions. So, does that mean you should back the Jets and Packers in a Week 16 NFL parlay?  

Which NFL trends and NFL betting lines could help with your NFL betting strategy? Before you make any Week 16 NFL picks or NFL parlays, you need to see what SportsLine senior analyst Larry Hartstein has to say. 

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed working for Pro Football Focus. Hartstein tied for 52nd place (out of 1,598 entries) in the 2022 Westgate Las Vegas SuperContest, going 53-34-3 ATS. His weekly Vegas contest selections form the basis of his NFL best bets column, which is 97-74-3 (57%, +14.65 units) since its inception in 2022. Anyone who has followed him is WAY UP!

For Week 16, Hartstein has locked in three confident best bets. If you successfully parlay his picks, you're looking at a payout of almost 6-1.

We can tell you Hartstein loves the 49ers (+1.5, 44.5) to cover on the road versus the Dolphins. "The 49ers' defense has gotten much better with the return of safety Talanoa Hufanga and linebacker Dre Greenlaw. Now Nick Bosa (limited practice Wednesday) could return along with starting safety Malik Mustapha. They'll shut down a flailing Miami attack that's missing Jaylen Waddle and has gotten declining production from De'Von Achane... The 49ers should have beaten the Rams on TNF, dropping two easy interceptions early, but I think they have a good shot to win out and salvage a winning record," Hartstein told SportsLine.

Hartstein also has locked in two other confident Week 16 bets, including backing a SHOCKING team whose "offense has come alive!" You ABSOLUTELY need to see his picks before betting on NFL Week 16.

So what are Hartstein's Week 16 NFL best bets, and which team shocks the NFL? ... Join SportsLine right now to see Larry Hartstein's Week 16 NFL best bets, all from the expert who is up 14.65 units on NFL ATS picks!