The lead in the AFC South will be on the line when the Jacksonville Jaguars hit the road to face the Houston Texans in a key Week 12 game on Sunday at NRG Stadium in Houston. The Jaguars (7-3) lead the division by one game over the Texans (6-4). Earlier this season, Houston routed Jacksonville, 37-17, in Week 3. Kickoff is scheduled for 1 p.m. ET. Jacksonville is a 1.5-point favorite in the latest Jaguars vs. Texans odds, while the over/under for total points scored is 48.5.

The game is one of 16 on the NFL schedule for Week 12, but which teams should you target with your NFL bets? Before you make any Week 12 NFL picks or NFL parlays, you need to see what SportsLine senior analyst Larry Hartstein has to say. 

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed working for Pro Football Focus. He tied for 52nd place (out of 1,598 entries) in the 2022 Westgate Las Vegas SuperContest, going 53-34-3 ATS. Those selections form the basis of his weekly SportsLine NFL best bets, which are 55-39-2 since the start of last season.

Now, Hartstein has locked in three confident Week 12 NFL best bets. If you successfully parlay his picks, you're looking at a payout of almost 6-1.

We can tell you Hartstein loves the Colts to cover against the Buccaneers. "This is a terrible spot for the Buccaneers, who will be playing their second straight road game following a 27-14 loss at San Francisco," Hartstein told SportsLine.

Hartstein also has locked in two other confident Week 12 NFL picks, including a play against an "inflated" team. You ABSOLUTELY need to see his picks before betting on NFL Week 12.

So what are Hartstein's Week 12 NFL best bets? And what inflated team is a play-against? ... Join SportsLine right now to see Larry Hartstein's Week 12 NFL best bets, all from the expert who went 53-34-3 in the SuperContest last year!