The NFL returns to Mexico for the first time since 2019 when the San Francisco 49ers and Arizona Cardinals collide in a Week 11 game on Monday Night Football at Estadio Azteca. The league has played in Mexico City five previous times, and the 49ers and Cardinals met in the NFL's first ever international game in 2005. This year, San Francisco (5-4) sits in second in the NFC West, while Arizona (4-6) is in third. 

Kickoff is 8:15 p.m. ET. San Francisco is an 8-point favorite in the latest NFL odds from Caesars Sportsbook, but which side should you back with your NFL bets and NFL predictions? Before you make any Week 11 NFL picks or NFL parlays, you need to see what SportsLine senior analyst Larry Hartstein has to say.

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. He entered the 2022 NFL season 427-344 all-time on NFL side picks (plus $3,764 for $100 players), including 394-330 against the spread. Hartstein went 68-50 ATS and 8-3 on money-line plays last season for a profit of $1,552.

Hartstein also is 17-13 on his best bets this season, including 11-7 the past six weeks.

Now, Hartstein has locked in three confident Week 11 NFL best bets. If you successfully parlay his picks, you're looking at a payout of almost 6-1.

We can tell you Hartstein loves the Patriots to cover against the Jets. "Zach Wilson has thrown seven interceptions in 2 1/2 games versus Bill Belichick's defense," Hartstein told SportsLine.

Hartstein also has locked in two other spread picks, including a STRONG play on a team with "an elite offense that's poised to erupt." You ABSOLUTELY need to see his picks before betting on NFL Week 11!

So what are Hartstein's Week 11 NFL best bets? And which offense is poised to erupt? ... Join SportsLine right now to see Larry Hartstein's Week 11 NFL best bets, all from the expert who entered the season up more than $3,700!