Just three weeks remain in the 2022 NFL regular-season schedule, and many games in Week 16 will have playoff implications. Among those is Cowboys vs. Eagles, where Dallas is a five-point favorite in the latest Week 16 NFL odds from Caesars Sportsbook. Other intriguing NFL matchups include Chiefs vs. Seahawks (+10), Giants vs. Vikings (-4) and Patriots vs. Bengals (-3). Before making any NFL picks, NFL survivor pool picks or NFL office pool picks for Week 16, see what the SportsLine Projection Model has to say.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 15 of the 2022 NFL season on an incredible 157-113 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

Now, the model has evaluated the latest odds from Caesars, simulated every snap for Week 16 of the 2022 NFL season, and the results are in. 

We can tell you one of the model's strongest Week 16 NFL picks is that the 49ers (-7) cover the spread at home against the Commanders well over 50% of the time. The model also says the Over (39.5) hits in well over 50% of simulations. The model's Week 16 NFL survivor picks say to avoid the Titans, even though they are touchdown favorites over the Texans, and one of the strongest Week 16 NFL office pool picks from the model is that the Bills beat the Bears.

The model has made the call on who wins and covers in every other game on the Week 16 NFL schedule, and it's calling for a shocking loss by a division leader! It's also backing a surprising team that's turned the corner in its NFL survivor picks! You ABSOLUTELY need to see its NFL picks for every single game, as well as its survivor predictions, before locking in your own.

So which NFL teams should you back this week? And which division leader goes down hard? ... Join SportsLine now to see who wins and covers every single game, and which SHOCKING survivor and office pool picks to make, all from the model that has returned more than $7,000 in profit on top-rated picks!