NFL odds, lines, spreads: 2026 Week 18 picks, predictions from proven model

Making NFL bets always carry a bit more excitement when they're made in a competitive game, and two such contests stick out in the Week 18 NFL schedule. There are a pair of winner-take-all games for playoff seeds with Seahawks vs. 49ers on Saturday, for the NFC's top seed, and Steelers vs. Ravens on Sunday night, for the AFC's last playoff berth. San Francisco is a 1.5-point home favorite, per the latest Week 18 NFL odds, while Baltimore is a 3.5-point road favorite. All 16 games that you can make Week 18 NFL picks on are divisional contests, with two on Saturday, 13 on Sunday afternoon and one on 'Sunday Night Football'.

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Some of the other contests with implications for playoff seeding include Texans vs. Colts (+10), Jaguars vs. Titans (+10.5) and Rams vs. Cardinals (+9.5). Meanwhile, the latest Week 18 NFL spreads have the Broncos as 7.5-point favorites over the Chargers, with Denver locking up the AFC's No. 1 seed with a win. Denver controls its own destiny for a postseason bye, and that motivation shouldn't be overlooked when making Week 18 NFL predictions.

Before locking in any NFL bets, make sure you see what SportsLine's advanced computer model has to say. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 17 on a 53-37 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has evaluated the latest NFL odds, simulated every snap for Week 18 of the 2025 NFL season, and the results are in.

We can tell you one of the model's strongest Week 18 NFL picks is that the Packers (+6.5, 36.5) cover versus Minnesota on Sunday at 1 p.m. ET. The model has Green Bay prevailing versus the spread nearly 70% of the time. Another one of its Week 18 NFL predictions: the Jaguars (-10.5, 46.5) cover versus the Titans in over 50% of simulations in a Sunday kickoff at 1 p.m. ET. The Over also hits 60% of the time.

The model has also made the call on who wins and covers in every other NFL game this week and just revealed SIX teams projected to win by double-digits! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!

So which NFL teams should you back in Week 18, and which six teams should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on 53-37 roll on top-rated NFL picks!

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