The Week 8 NFL schedule has a season-high of six teams on byes, meaning there aren't quite as many matchups to place Week 8 NFL bets on. However, that also means you can devote more of your NFL betting strategy on these matchups, which include a pair of Sunday games pitting two winning teams versus one another. Bills vs. Panthers has Buffalo as 7.5-point road favorites, per the Week 8 NFL odds, while Packers vs. Steelers on Sunday night has Green Bay favored by 3 points on the road as Aaron Rodgers will face his former team.

The biggest Week 8 NFL spread comes courtesy of Colts vs. Titans (+14.5), which is also one of three divisional games on the slate. Others include Eagles vs. Giants (+7.5), as the two play for the second time in 18 days. There's also Buccaneers vs. Saints (+3.5), as the Bucs will follow a MNF road game with a trip to New Orleans. Meanwhile, there was a big line shift with Lamar Jackson (hamstring) being ruled out versus Chicago, with the Ravens going from 7.5-point favorites to now being favored by 2.5 points.

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The week's schedule concludes with the Chiefs back on primetime after a one-week reprieve. Kansas City (-11.5) will host the Commanders on Monday, with Jayden Daniels' (hamstring) ruled out. However, backup Marcus Mariota will have the services of returning wideouts Terry McLaurin and Deebo Samuel.

Before locking in any NFL bets, make sure you see what SportsLine's advanced computer model has to say. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 43-28 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has evaluated the latest NFL odds, simulated every snap for Week 8 of the 2025 NFL season, and the results are in.

We can tell you one of the model's strongest Week 8 NFL picks is that the Browns (+7, 40.5) cover at New England in a Sunday 1 p.m. ET kickoff. The model has Cleveland prevailing versus the spread well over 50% of the time. Another one of its Week 8 NFL predictions: the Falcons (-7.5, 44.5) cover versus the Dolphins in over 50% of simulations. The model also says the Over hits in over 60% of simulations.

The model has also made the call on who wins and covers in every other NFL game this week and just revealed FIVE teams that win in nearly 70% of simulations or more! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!

So which NFL teams should you back in Week 8, and which five teams should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on 43-28 roll on top-rated NFL picks!

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