It's always a treat when fans are treated to matchups featuring two good teams, and there's no shortage of them to make Week 7 NFL predictions on. The last London game of 2025 will see Rams vs. Jaguars (+3), and then on Sunday at 1 p.m. ET, we will have Eagles vs. Vikings (+2.5). In the late afternoon at 4:05 p.m. ET, the latest Week 7 NFL odds have the Chargers as 2.5-point favorites versus the Colts, with both teams possessing sneaky MVP candidates at quarterback in Justin Herbert and Daniel Jones.

Monday features another doubleheader, with the first matchup being a potential playoff preview of Lions vs. Buccaneers. Another pair of MVP candidates, in Jared Goff and Baker Mayfield, are under center for that contest, which has Detroit favored by 5.5 points, per the Week 7 NFL spreads.

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If you prefer matchups with a struggling team to make NFL predictions on, you'll also have a wide selection. Such contests include the Saints (+4) versus the Bears, the winless Jets (+1.5) against the Panthers and the Cardinals (+7) hosting the Packers, with Arizona expected to be without Kyler Murray.

Before locking in any NFL bets, make sure you see what SportsLine's advanced computer model has to say. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 42-25 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has evaluated the latest NFL odds, simulated every snap for Week 7 of the 2025 NFL season, and the results are in.

We can tell you one of the model's strongest Week 7 NFL picks is that the Vikings (+1.5, 43.5) cover at home versus the Eagles in a Sunday 1 p.m. ET kickoff. The model has Minnesota prevailing versus the spread over 50% of the time. Another one of its Week 7 NFL predictions: the Broncos (-7, 40.5) cover versus the Giants in well over 50% of simulations. The model also says the Over hits well over 50% of the time.

The model has also made the call on who wins and covers in every other NFL game this week and just revealed FOUR teams that win by nearly 70% of simulations or more! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!

So which NFL teams should you back in Week 7, and which four teams should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on 42-25 roll on top-rated NFL picks!

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