A week after seizing control of the AFC South with a shootout victory over the Seattle Seahawks 38-35, the Tampa Bay Buccaneers will face another stiff test when they battle the NFC West-leading San Francisco 49ers. San Francisco is coming off a 26-23 victory over the Los Angeles Rams. The Buccaneers are 2-1 in the conference, while the 49ers are 4-0 against NFC foes. The Bucs are -3.5 in this matchup where both teams are dealing with some major injuries.

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Baker Mayfield is coming off a monster game for the Buccaneers, completing 29 of 33 passes (87.9%) for 379 yards and two touchdowns. He also carried five times for 15 yards. For the season, Mayfield has completed 112 of 172 passes (65.1%) for 1,283 yards and 10 touchdowns with one interception as he's suddenly an NFL MVP contender. He is in his third season with Tampa Bay, throwing for more than 4,000 yards in each of the last two years.

There are a number of intriguing matchups on the Week 6 NFL schedule Rams vs. Ravens (+7.5) with Lamar Jackson ruled out, Seahawks vs. Jaguars (-1.5), Lions vs. Chiefs (-2.5) on Sunday Night Football and Bears vs. Commanders (-4.5) on Monday Night Football. Which other teams have value to include in Week 6 NFL parlay bets, and which side of the NFL odds should you target?

Before you lock in any NFL bets, make sure you see what SportsLine's advanced computer model has to say. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 41-21 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

The model has scoured the Week 6 NFL odds and locked in five confident NFL best bets. If you successfully parlay its sports betting picks, you'd be looking at a massive payout of around 24-1. 

One pick we'll give away: The model is backing the Bills (-4.5) to cover against the Falcons 70% of the time.

The model is also backing a surprising underdog that it says will not only cover, but win outright! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!

So which NFL teams should you back in Week 6, and which five picks should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on a 41-21 roll on top-rated NFL picks!

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