The Buffalo Bills can seize complete control of the AFC East when they take on the New England Patriots on Sunday Night Football. A win would give Buffalo a three-game lead over the second-place Patriots just five weeks into the season. Ever since rallying for a 41-40 win over the Baltimore Ravens in the season opener, the Bills have dominated. The model is high on Buffalo (-8.5, 49.5) to cover against the visiting Patriots on Sunday Night Football. New England leads the all-time series 79-51-1, but the Bills have won eight of the past 11 meetings.

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Josh Allen is playing at an MVP-type level so far this season. In four games so far in 2025, he has completed 85 of 121 passes (70.2%) for 964 yards and seven touchdowns with one interception. He has also carried 31 times for 159 yards (5.1 average) and three touchdowns. In seven-plus seasons, he has completed 63.5% of his passes for 27,398 yards and 202 touchdowns with 85 interceptions.

There are a number of intriguing matchups on the Week 5 NFL schedule, including Vikings vs. Browns (+3.5) in London, Texans vs. Ravens (-3.5), Raiders vs. Colts (-6.5), Cowboys vs. Jets (+2.5), Lions vs. Bengals (+10) and Chiefs vs. Jaguars (+3.5) on Monday Night Football. Which other teams have value to include in Week 5 NFL parlay bets, and which side of the NFL odds should you target?

Before you lock in any NFL bets, make sure you see what SportsLine's advanced computer model has to say. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 39-20 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

The model has scoured the Week 5 NFL odds and locked in five confident NFL best bets. If you successfully parlay its sports betting picks, you'd be looking at a massive payout of around 24-1. 

One pick we'll give away: The model is backing the Vikings (-3.5) to cover against the Browns nearly 60% of the time.

The model is also backing a surprising underdog that it says will not only cover, but win outright! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!

So which NFL teams should you back in Week 5, and which five picks should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on a 39-20 roll on top-rated NFL picks!

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