There are lots of slim Week 5 NFL spreads to make NFL picks on, as only three contests have a line of more than a touchdown. The outliers are Cardinals vs. Titans (+7.5), Lions vs. Bengals (+10.5) and Bills vs. Patriots (+8) on Sunday Night Football. As for those smaller spreads, per the Week 5 NFL odds, some of those games include Giants vs. Saints (-1.5), Eagles vs. Broncos (+4.5), Chargers vs. Commanders (+2.5), as Jayden Daniels will return to the lineup, and Chiefs vs. Jaguars (+3.5) on Monday night.

No team has a perfect spread record entering the Week 5 NFL schedule, which could make it a bit tricky in deciding who to back with your football predictions. However, with bye season hitting and four teams having off, you can devote a bit more time and energy into those Week 5 NFL picks you plan on making.

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Dolphins vs. Panthers (+1.5) features a pair of teams who could be in the running for the top overall pick in next year's draft. They're also involved in the game with the smallest of NFL spreads. Before locking in any NFL bets, make sure you see what SportsLine's advanced computer model has to say. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 39-20 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has evaluated the latest NFL odds, simulated every snap for Week 5 of the 2025 NFL season, and the results are in.

We can tell you one of the model's strongest Week 5 NFL picks is that the Saints (-1.5, 41.5) cover the spread versus the Giants in a Sunday 1 p.m. ET kickoff. The model has New Orleans prevailing versus the spread over 50% of the time. Another one of its Week 5 NFL predictions: the Cardinals (-7.5 41.5) cover versus Tennessee in well over 50% of simulations. The model also says the Over hits over 50% of the time.

The model has also made the call on who wins and covers in every other NFL game this week and just revealed FOUR coveted A-rated spread picks! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!

So which NFL teams should you back in Week 5, and which four teams should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on 39-20 roll on top-rated NFL picks!

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