The Week 4 NFL schedule is the last one before byes start, and it's also the second to have a two-game MNF slate. Monday's schedule starts in Miami, where the Dolphins are favored by 2.5 points over the Jets, per the Week 4 NFL odds in a matchup of winless squads. It then ends in Denver, with Broncos vs. Bengals (+7.5, 44). However, the game bettors will most target with Week 4 NFL predictions is sure to be Chiefs vs. Ravens on Sunday at 4:25 p.m. ET.

Patrick Mahomes and Lamar Jackson are both two-time MVPs, and it's the road Ravens who are favored by 2.5 points according to the latest NFL lines, with an O/U of 48.5. That's despite Kansas City winning six of the last seven meetings between the squads. That is one of six games with an NFL spread of a field goal or less for Week 4, while three others have an NFL line of 3.5 points.

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On the other end of the spectrum, the undefeated Bills are favored by 14.5 points over the winless Saints in the largest Week 4 NFL spread, and the biggest line of the 2025 NFL season. Just five games all of last season had a spread of over two touchdowns. Detroit is now a double-digit favorite against the Browns as that spread has moved from -9.5 to -10. 

Before locking in any NFL bets, make sure you see what SportsLine's advanced computer model has to say. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 39-19 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has evaluated the latest NFL odds, simulated every snap for Week 4 of the 2025 NFL season, and the results are in.

We can tell you one of the model's strongest Week 4 NFL picks is that the Chargers (-6.5, 44) cover the spread at the Giants in a Sunday 1 p.m. ET kickoff. The model has Los Angeles prevailing versus the spread well over 50% of the time. Another one of its Week 4 NFL predictions: the Bears (+1.5, 48) cover at Vegas in almost 60% of simulations in an A-rated spread pick. The model also says the Under hits well over 50% of the time.

The model has also made the call on who wins and covers in every other NFL game this week and just revealed four teams that win straight-up in over 70% of simulations! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!

So which NFL teams should you back in Week 4, and which four teams should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on 39-19 roll on top-rated NFL picks!

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