With a pair of weeks in the books, NFL betting trends should start emerging, which will only help with making Week 3 NFL picks. Away favorites are covering nearly 62% of the time, and there are a number of road teams favored on the Week 3 NFL schedule. Panthers vs. Falcons (-5.5), Browns vs. Packers (-7.5), Patriots vs. Steelers (-1.5) and Giants vs. Chiefs (-6) on Sunday night all see the favored team going on the road, yet giving points. For Week 3 NFL betting, you'll have to decide if the early-season trends continue and if you should back these road favorites with Week 3 NFL predictions.

Other contests to look forward to this week include Rams vs. Eagles (-3.5), a rematch from last season's playoffs, and a potential Super Bowl preview on Monday night with Lions vs. Ravens (-4.5). Meanwhile Bengals vs. Vikings (-3) is an interesting matchup for NFL predictions as both teams will be without their starting quarterbacks as Carson Wentz goes for Minnesota and Jake Browning starts for Cincinnati.

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We're treated to large NFL spreads this week as there are a total of four games with a line of at least 7 points, per the latest Week 3 NFL odds. Before you lock in any NFL bets, make sure you see what SportsLine's advanced computer model has to say. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 37-17 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has evaluated the latest NFL odds, simulated every snap for Week 3 of the 2025 NFL season, and the results are in.

We can tell you one of the model's strongest Week 3 NFL picks is that the Packers (-7.5, 41.5) cover the spread at Cleveland in a Sunday 1 p.m. ET kickoff. The model has Green Bay prevailing versus the spread over 60% of the time. Another one of its Week 3 NFL predictions: the Colts (-4.5, 43.5) cover at Tennessee in well over 50% of simulations. The model also says the Over hits well over 60% of the time.

The model has also made the call on who wins and covers in every other NFL game this week and just revealed two coveted A-rated spread picks! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!

So which NFL teams should you back in Week 3, and which two teams should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on 37-17 roll on top-rated NFL picks!

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