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NFL odds, lines, spreads: 2025 Week 2 picks, predictions from proven model: 5-way parlay pays almost 25-1

The SportsLine Projection Model, which is up well over $7,000 for $100 players on top-rated NFL picks since its inception, has revealed its Week 2 NFL 25-1 parlay

ByPublished: Sep 14, 2025 4:01PM UTC . 3 min read

The Detroit Lions will look to rebound after a rough season-opening loss to the NFC North-rival Green Bay Packers in Week 1. The defending NFC North champion Lions will get that chance when they meet the Chicago Bears in their home opener on Sunday. The model is high on the Lions (-6.5, 46.5) to cover against the Bears. Detroit won both meetings last season, including a 23-20 win in Detroit on Thanksgiving Day, and the Lions have won five of the last six versus Chicago.

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The Lions will be led by veteran quarterback Jared Goff, who completed 31 of 39 passes (79.5%) for 225 yards and one touchdown in the 27-13 loss to the Packers. In 17 games last season, he completed 72.4% of his passes for 4,629 yards and 37 touchdowns with just 12 interceptions and a rating of 111.8 as Goff finished fifth in MVP voting.

Other divisional matchups on the Week 2 NFL schedule include Browns vs. Ravens (-12), which has the largest NFL spread of the season, Giants vs. Cowboys (-5.5), Patriots vs. Dolphins (-2.5), Bills vs. Jets (+6.5) and Chargers vs. Raiders (+3.5) on Monday night. Which other teams have value to include in Week 2 NFL parlay bets, and which side of the NFL odds should you target?

Before you lock in any NFL bets, make sure you see what SportsLine's advanced computer model has to say. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a 33-17 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

The model has scoured the Week 2 NFL odds and locked in five confident NFL best bets. If you successfully parlay its sports betting picks, you'd be looking at a massive payout of around 24-1. 

One pick we'll give away: The model is backing the Lions (-6.5) to cover against the Bears nearly 60% of the time.

The model is also backing a surprising underdog that it says will not only cover, but win outright! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!

So which NFL teams should you back in Week 2, and which five picks should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on a 33-17 roll on top-rated NFL picks!

LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month for $1 JOIN NOW.

GET VEGAS EXPERT PICKS FOR NFL, MLB, NBA, CBB, GOLF, NHL, HORSE RACING AND MORE - PLUS ADVANCED COMPUTER SIMULATIONS, WINNING TOOLS, AND MORE!

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Daniel Kohn

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