We won't have to wait until Super Bowl 2026 to, potentially, see the Chiefs and Eagles matching up again, as the two will face off during the Week 2 NFL schedule. Kansas City was a 1-point favorite in last season's Big Game, but the Eagles are favored by 1.5 points for Sunday's matchup, per the latest Week 2 NFL odds. 

Other contests with NFL spreads of a field goal or less include Dolphins vs. Patriots (+2.5), Steelers vs. Seahawks (+3), 49ers vs. Saints (+3), Broncos vs. Colts (+2.5) and Buccaneers vs. Texans (-2.5), on Monday night.

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Just one game doesn't define a team's season, but what can you gather from the opening slate to assist with Week 2 NFL bets? Before you lock in any NFL bets, make sure you see what SportsLine's advanced computer model has to say. 

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a 33-17 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has evaluated the latest NFL odds, simulated every snap for Week 2 of the 2025 NFL season, and the results are in.

We can tell you one of the model's strongest Week 2 NFL picks is that the Cowboys (-5.5, 44.5) cover the spread at home versus the Giants. The model has Dallas prevailing versus the spread nearly 60% of the time. Another one of its Week 2 NFL predictions: the Cardinals (-6.5, 44.5) cover at home versus the Panthers in almost 60% of simulations. The model also says the Over hits 60% of the time.

The model has also made the call on who wins and covers in every other NFL game this week and just revealed THREE coveted A-rated spread picks! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!

So which NFL teams should you back in Week 2, and which three teams should you lock in RIGHT NOW? ... Join SportsLine now to see who wins and covers every single NFL game this week, all from the model on 33-17 roll on top-rated NFL picks!

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